Urosphere - Experimental models for BPH urinary incontinence overactive bladder sexual dysfunction human tissue

OFFERING

UROsphere focuses on studies and offers to its customers a wide range of models and assays in order to meet specific requirements. If studies require specific techniques, it can be carried out with scientific partnerships.

Multiple species

rat guinea-pig mouse pig rabbit human

Multiple models

Normal conditions
Cystitis (acute and chronic)
Acute bladder irritation
Neurogenic bladder
Benign Prostatic Hyperplasia (BPH)
Erectile dysfunction

Renal function
Renal fibrosis
Renal ischemia
Diabetic nephropathy

Multiple techniques

In vivo

Cystometry in anesthetized and conscious animals
Cystometry in isovolumetric conditions
Simultaneous recording of urethral and vesical pressures
Recording of micturition volumes in metabolic cages
Evaluation of sexual dysfunction

Isolated animal and human tissues

in vitro pharmacology assays with human tissues
Myogenic and neurogenic contraction/ relaxation of isolated tissues
Pharmacological characterization of receptors on cells and tissues

Differential gene expression profile

Quantitative RT-PCR

Histomorphometry

OFFERING BY PATHOLOGIES

click on the model of interest to obtain more information.

Urinary Incontinence, Overactive Bladder (OAB), Painful Bladder Syndrome / Insterstitial Cystitis

in vivo pharmacological models
- Cystometry in unirritated bladder model
- Cystometry in an irritated bladder model
- Cystometry in Bladder Outlet Obstruction model
- Cystometry under isovolumetric conditions
- Cystometry in sub-chronic inflammatory conditions
- Cystometry in acute inflammatory conditions
- Cystometry after Spinal Cord Injury NEW

- Urethral pressure measurement
- Simultaneous recording of urethral and vesical pressures

in vitro pharmacological assays
- Functional pharmacology assays in isolated bladder NEW

Benign Prostatic Hyperplasia (BPH)

in vivo pharmacological models
- Cystometry in Bladder Outlet Obstruction
- Prostate enlargment

in vitro pharmacological assays
- Functional pharmacology assays in isolated prostate NEW

Sexual dysfunctions

in vivo pharmacological models
- Penile erection (in collaboration with Porsolt and Partners Pharmacology)

in vitro pharmacological assays
- Functional pharmacology assays on isolated corpus cavernosum NEW

Renal disorders - Urolithiasis

in vivo pharmacological models
- Renal fibrosis
- Ischemia Reperfusion injury
- Diabetic nephropathy
- Renal function
- Arterial blood pressure

in vitro pharmacological assays
- Human isolated ureters

- Renal cells in culture