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human tissue assays







laboratory material










pathophysiological model













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Experimental-models

OFFERING

UROsphere focuses on tailor-made studies and offers to its customers a wide range of models and assays in order to meet specific requirements. If studies require specific techniques, it can be carried out with scientific partnerships.


Multiple species



rat    guinea-pig    mouse    pig    rabbit     human






Multiple models


  • Normal conditions
  • Cystitis (acute and chronic)
  • Acute bladder irritation
  • Benign Prostatic Hyperplasia (BPH)
  • Renal fibrosis
  • Renal ischemia
  • Diabetic nephropathy
  • Erectile dysfunction











Multiple techniques
    In vivo

  • Cystometry in anesthetised and conscious animals
  • Urethral pressure measurements
  • Arterial blood pressure
  • Evaluation of sexual dysfunction

Isolated animal and human tissues

  • Myogenic and neurogenic contractility of isolated tissue
  • Contractility of human isolated tissues
  • Histomorphometry

Cell assays

  • Pharmacological characterisation of receptors on cells and tissues
  • Signal transduction
  • Detection of apoptosis
  • Oxidative stress and proliferation analyses

Gene expression profile

  • Quantitative RT-PCR



OFFERING BY PATHOLOGIES

click on the model of interest to obtain more information


urinary incontinenceUrinary Incontinence 

- Cystometry in unirritated bladder model
-
Cystometry in irritated bladder
-
Cystometry in Bladder Outlet Obstruction
- Cystometry in sub-chronic inflammatory conditions
Cystometry in acute inflammatory conditions NEW
- Cystometry under isovolumetric conditions NEW
- Cystometry after spinal cord injury (under implementation)

-
Bladder and urethra isolated smooth muscle
-
Human urinary bladder and urethra tissues

BPHBenign Prostatic Hyperplasia (BPH)

-
Cystometry in Bladder Outlet Obstruction
- Prostate enlargment

-
Human prostatic adenoma
- Bladder and urethra isolated smooth muscle

sexual dysfunctionsSexual dysfunctions

-
Isolated corpus cavernosum
- Penile erection (in collaboration with Porsolt and Partners Pharmacology)

renal disordersRenal disorders - Urolithiasis

- Renal fibrosis
- Ischemia Reperfusion injury
-
Diabetic nephropathy
- Renal function  
Arterial blood pressure  

- Human isolated ureters
- Renal cells in culture