Process

Our specialized experimental research platform dedicated to urogenital pathologies consists of both in vivo and in vitro pharmacological assays.

Isolated tissues assays

• Species: human, rat, rabbit, mouse, guinea-pig (others upon request)
• Tissues: bladder, urethra, ureters, myometrium, prostate, others (include uterus, corpus cavernosum, vas deferens, seminal vesicles, blood vessels)
• Myogenic and neurogenic contractions
• Data provide information on the pharmacological characterization of the compound (potency and efficacy, reversibility of drug action)
• More information on human tissue services

Biochemical markers of lower urinary tract inflammation

• More information on biochemical markers

Differential gene expression

We provide a combination of multiple species, techniques and validated animal models for lower urinary tract pathologies.

- Species: rat, rabbit, mouse, guinea-pig (others upon request)

- Animals: normal or genetically modified

- Techniques: 

• Cystometry in anesthetized and conscious animals
• Cystometry in isovolumetric conditions
• Simultaneous recording of urethral and vesical pressure
• Recording of micturition pattern and urine volumes in metabolic cages
• EMG recording of the urethral sphincter
• Evaluation of sexual function
• Pharmacokinetics studies: administration of drugs by different routes and collection of plasma and urine samples for drug quantification
  
• Biochemical markers of lower urinary tract inflammation

- Animal models:

• Normal conditions
• Cystitis (acute and chronic)
• Acute bladder irritation
• Neurogenic bladder (spinal cord injury)
• Benign Prostatic Hyperplasia (BPH)
• Erectile dysfunction
• Renal pathologies including renal fibrosis, ischemia reperfusion, diabetic nephropathy

- Data provide information on the mechanism of action of the compound in physiological or physiopathological conditions, potency, efficacy, onset and duration of action, etc. .