URINARY BLADDER FUNCTION

A MODEL OF NORMAL BLADDER FUNCTION

Cystometry in conscious animals without compromised bladders.

Confounding factors due to anesthetics and bladder manipulation which can complicate interpretation of results are avoided in this model.
 

Rat, mouse, guinea-pig
 

• This model is suitable for testing the effects of compounds on the entire micturition system.
• Cardiovascular parameters can be monitored simultaneously to verify functional uroselectivity.

• Cystometry during continuous infusion of intravesical saline.
• Test compounds can be administered via various routes (i.v., i.p., p.o., s.c. or by osmotic pumps) and cystometric parameters evaluated for up to two hours post-administration.

• Bladder capacity
• Intercontraction intervals during cystometry
• Micturition pressure
• Micturition volume
• Basal intravesical pressure
• Threshold pressure for micturition

• Lluel P et al, Neurourol Urodyn 21: 142-53, 2002
• Matsuura S and Downie JW, Neurourol Urodyn 19: 87-99, 2000
• Lluel P et al, J Urol 160: 2253-57, 1998