BIOMARKER ANALYSIS

QUANTITATIVE ANALYSIS WHICH CAN HELP TO DEFINE MECHANISM OF ACTION FOR TARGETED THERAPEUTICS

• Quantitative analysis of specific biomarkers can be useful establishing an etiologic mechanism in generating a definitive diagnosis and in predicting a treatment response.
• Recently biomarker analysis has become critical to explore drug safety and efficacy.
• UROsphere can assess a variety of biomarkers in different preclinical models.

• Enzymatic assays: colorimetry, fluorescent
• Immunochemistry assays: EIA and ELISA tests

• Plasma
• Urine
• Tissue

• Neuroimmune biomarkers: NGF, SP, CGRP
• Inflammatory biomarkers: arachidonic acid metabolites (PGE2, LTB4, TXB2) (in collaboration with Ambiotis)
• Standard biomarkers: myeloperoxidase activity, creatinine, total protein

UROsphere can also evaluate the feasibility of additional biomarkers to meet clients’ needs.

• Lluel P et al, ICS Annual meeting, San Francisco, USA, 2009