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Stimulation of beta3- adrenoceptors inhibits EFS-induced contraction of human isolated urinary bladder

Rekik M, Rouget C, Camparo P, Botto H, Lluel P, Westfall TD, Palea S.

J Urol 183 (4, sup): e190, 2010.

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Antagonistic effects of ADTX1 and tamsulosin in human isolated prostatic adenoma and recombinant human alpha1A adrenoceptors.

Palea S, Rekik M, Rischmann P, Lluel P, Gilles N.

J Urol 183 (4, sup): e1422, 2010.

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Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor

Quinton L, Girard E, Maiga A, Rekik M, Lluel P, Masuyer G, Larregola M, Marquer C, Ciolek J, Magnin T, Wagner R, Molgó J, Thai R, Fruchart-Gaillard C, Mourier G, Chamot-Rooke J, Ménez A, Palea S, Servent D, Gilles N.

Br J Pharmacol 159 (2): 316-325, 2010. Abstract

Involvement of ß3-adrenoceptors in mouse urinary bladder function: role in detrusor muscle relaxation and micturition reflex.

Deba A, Palea S, Rouget C, Westfall TD, Lluel P.

Eur J Pharmacol  618: 76-83, 2009. Abstract 

AdTx1, a new peptidic alpha1A-adrenoceptor antagonist: in vivo pharmacological characterization.

Palea S, Gilles N, Guerard M, Lluel P.

J Urol 181 (4, sup): 1416, 2009.

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Differential gene expression in bladder hypertrophy following bladder outlet obstruction in mouse.

Deba A, Palea S, Parini A, Lluel P.

J Urol 181 (4, sup): 1412, 2009.

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Netupitant, a new selective NK1 receptor antagonist, reverses acetic acid-induced bladder overactivity in anesthetized female guinea-pigs.

Lluel P, Guilloteau V, Guerard M, Pietra C, Lovati E, Palea S.

J Urol 181 (4, sup): 1585, 2009.

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Functional evidence of ß3-adrenoceptors (ß3-AR) in female mouse isolated urinary bladder.

Deba A, Lluel P, Palea S.

J Urol 181 (4, sup): 420, 2009.

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AdTx1, a new peptidic alpha1-adrenoceptor antagonist with high affinity and selectivity for human alpha1A-adrenoceptor subtype: pharmacological characterization.

Gilles N, Lluel P, Rekik M, Guerard M, Palea S.

Eur Urol  S8: 358, 2009.

Comparative effect of alfuzosin and tamsulosin on the contractile response of isolated rabbit prostatic and iris dilator smooth muscles: a possible model for intraoperative floppy iris syndrome (IFIS).

Palea S, Chang D F, Rekik M, Regnier A, Lluel P.

J Cataract Refract Surg 34 (3): 489-496, 2008.

Alfuzosin reverses bladder overactivity induced by cyclophosphamide in conscious rats.

Lluel P, Guilloteau V, Palea S.

J Urol 179 (4, sup): 371, 2008.

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Tadalafil exerts an additive effect on alfuzosin-induced relaxation in pre-contracted human isolated prostatic adenoma.

Palea S, Rekik M, Rischmann P, Botto H, Lluel P.

J Urol 179 (4, sup): 1324, 2008.

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Purinergic receptor subtypes involved in bladder contraction in anesthetized mice.

Deba A, Lluel P, Palea S.

J Urol 179 (4, sup): 372, 2008.

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Role of ß3-adrenoceptors in mouse isolated urinary bladder.

Deba A, Palea S, Lluel P.

Eur Urol  S7: 182, 2008.

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Propriétés pharmacologiques de l'oxybutynine sur la fonction vésicale chez la souris.

Deba A, Lluel P, Palea S.

Pelv Perineol 2: 12-19, 2007.

Alfuzosin, but not tamsulosin, relieves bladder hypertrophy in rats despite a persistent bladder outlet obstruction.

Lluel P, Méen M, Maurel A, Heudes D, Bruneval P, Palea S.

Urology 70 (3A, sup): 153-154, 2007.

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Comparison of the effects of besipirdine, its main metabolite and duloxetine on urethral pressure in anesthetized female rats.

Lluel P, Guerard M, Méen M, Ferté J, Bienaymé H, Attali P, Palea S.

Neurourol Urodyn 26: 674, 2007.

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Intra-operative floppy iris syndrome: at therapeutic doses alfusozin does not impact isolated rabbit iris dilator smooth muscle while tamsulosin does.

Palea S, Rekik M, Lluel P.

J Urol 177 (4, sup): 447, 2007.

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The selective ß3-adrenoceptor agonist CL316,243, potently modifies cystometric parameters in anesthetized mice: comparison with oxybutynin.

Lluel P, Deba A, Palea S.

J Urol 177 (4, sup), 2007.

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Effects of besipirdine and its main metabolite on the contractility of the rabbit isolated urethra.

Palea S, Rekik M, Ferte J, Bienayme H, Lluel P.

Neurourol Urodyn 25: 585-586, 2006.

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Alfuzosin reverses bladder hypertrophy induced by bladder outlet obstruction in rats.

Lluel P, Méen M, Palea S.

Eur Urol  S5: 121, 2006.

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Mesure simultanée de la salivation et de la pression intravésicale chez la souris anesthésiée: effets de l'oxybutynine

Deba A, Lluel P, Palea S.

Pelv Perineol 1: 93-94, 2006.

Increased adrenergic contractility and decreased mRNA expression of NOS III in aging rat urinary bladders.

Lluel P, Palea S, Ribière P, Barras M, Teillet L and Corman B.

Fund Clin Pharmacol 17: 633-41, 2003. Abstract

Involvement of 5-HT7 receptors in the 5-HT excitatory effects on the rat urinary bladder.

Palea S, Lluel P, Barras M, Duquenne C, Galzin AM, Arbilla S.

BJU Int  94: 1125-31, 2004. Download publication

Comparison of the effects of alfuzosin and sildenafil on the rabbit isolated corpus cavernosum.

Barras M and Palea S.

 BJU Int 91: 873-7, 2003. Download publication

Age-related changes in urethro-vesical coordination in male rats: relationship with bladder instability.

Lluel P, Deplanne V, Heudes D, Bruneval P and Palea S.

Am J Physiol Regul Integr Comp Physiol 284: R1287-95, 2003. Download publication

Functional and morphological modifications of the urinary bladder in aging female rats.

Lluel P, Palea S, Barras M, Grandadam F, Heudes D, Bruneval P, Corman B, Martin DJ.

Am J Physiol Regul Integr Comp Physiol 278: R964-72, 2000. Download publication

SSR240600, a selective neurokinin NK1 receptor antagonist, reduces micturition frequency in anesthetized female guinea-pigs and may be useful as a treatment of human OAB.

Lluel P et al.

Aspet-Ray Fuller Symposium, Lower Urinary Tract Disorders, July 6-7, 2002.

Cholinergic and purinergic contribution to the micturition reflex in conscious rats with long-term bladder outlet obstruction.

Lluel P, Barras M, Palea S.

Neurourol Urodyn 21: 142-153, 2002.

Antagonist effects of alfuzosin on concentration-response curves to phenylephrine and noradrenaline in human prostatic adenoma.

Palea S, Barras M, Deplanne V, Vallancien G.

Neurourol Urodyn 19: 431-33, 2000.

Functional uroselectivity of SL 91.0893 a new alpha1-adrenoceptor antagonist.

Lluel P, Rauch C, George P, Marabout B, Martin D.

Eur Urol 36: 113-117, 1999.

Pharmacological and urodynamic changes in rat urinary bladder function after multiple pregnancies.

Grandadam F, Lluel P, Palea S, Martin DJ.

BJU Int 84: 861-6, 1999. Download publication

Involvement of spinal NK1 and opioids receptors in modulating the inhibitory effects of capsaicin on micturition reflex in the acute spinalized guinea pigs.

Palea S and Pietra C.

J Urol 161: 998-1005, 1999. Abstract

Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder.

Palea S, Toson G, Pietra C, Trist DG, Artibani W, Romano O, Corsi M.

Br J Pharmacol 124: 865-72, 1998. Abstract

The adrenergic, cholinergic and NANC nerve-mediated contractions of the female rabbit bladder neck and proximal, medial and distal urethra.

Deplanne V, Palea S, Angel I.

Br J Pharmacol 123: 1517-24, 1998.  Abstract

Contractile activity of NS-49 in female rabbit lower urinary tract and mesenteric artery.

Barras M, Palea S, Martin, D.

Eur Urol 36: 113-117, 1999. 

Experimental bladder instability following bladder outlet obstruction in the female rat.

Lluel P, Duquenne C, Martin D.

J Urol 160: 2253-7, 1998. Abstract

Relationship between the effects of alfuzosin on rat urethral and blood pressures and its tissue concentrations.

Martin DJ, Lluel P, Pouyet T, Rauch-Desanti C, Angel I.

Life Sci 63: 169-76, 1998.

Potent contractile activity of NS-49 on female rabbit isolated urethra and trigone.

Barras M, Palea S, Martin D, Angel I.

NS Arch Pharmacol 358: R259, 1998.

sGuanylate Cyclase activation during field-stimulation-induced relaxation of rabbit corpus cavernosum.

Palea S, Barras M, Martin D, Angel I.

NS Arch Pharmacol 358: R259, 1998.

Pharmacological studies on smooth muscle relaxation of rabbit isolated corpus cavernosum.

Barras M, Palea S, Martin D, Angel I.

NS Arch Pharmacol 358: R260, 1998.

Pharmacological characterization of 5-HT potentiating effects on electrically-induced contractions in dog, pig and rat detrusor muscle.

Martin D, Barras M, Palea S.

Neurourol Urodyn 17: 337-39, 1998.

The effect of ovariectomy on the contractile response of the rat isolated detrusor muscle and urethra.

Palea S and Angel I.

Life Sci 61: PL21-6, 1997. Abstract

Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists.

Martin DJ, Lluel P, Guillot E, Coste A, Jammes D, Angel I.

J Pharmacol Exp Ther 282:228-35, 1997. Download publication

Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.

Palea S, Corsi M, Artibani W, Ostardo E, Pietra C.

J Pharmacol Exp Ther 277:700-5, 1996. Abstract

Evidence for the presence of both pre- and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder.

Palea S, Pietra C, Trist DG, Artibani W, Calpista A, Corsi M.

Br J Pharmacol 114: 35-40, 1995. Abstract

Discrimination by benextramine between the NPY-Y1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein.

Palea S, Corsi M, Rimland JM, Trist DG.

Br J Pharmacol 115: 3-10, 1995. Abstract

Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.

Palea S, Corsi M, Rimland JM, Trist DG, Ratti E.

Br J Pharmacol 116: 2401-6, 1995. Abstract

A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.

Corsi M, Palea S, Pietra C, Oliosi B, Gaviraghi G, Sugg E, Van Amsterdam FT, Trist DG.

J Pharmacol Exp Ther 270:734-40, 1994. Abstract

ADP beta-S induces contraction of the human isolated urinary bladder through a purinoceptor subtype different from P2X and P2Y.

Palea S, Corsi M, Pietra C, Artibani W, Calpista A, Gaviraghi G, Trist DG.

J Pharmacol Exp Ther 269:193-7, 1994.

Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis.

Palea S, Artibani W, Ostardo E, Trist DG, Pietra C.

J Urol 150: 2007-12, 1993. Abstract

Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK1 receptor mediated excitatory and inhibitory activity.

Palea S, Dalforno G, Gaviraghi G, Hagan RM, Trist DG, Pietra C.

Neuropeptides 24: 285-91, 1993. Abstract

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