URETHRAL PRESSURE MEASUREMENTS

A MODEL FOR STRESS OR MIXED URINARY INCONTINENCE

Measurement of urethral pressure in anesthetized animals.

Rat, guinea-pig

• This model is suitable for testing compounds for effects on urethral pressure.
• Compounds that produce effects on this experimental model include α₁-adrenoceptor agonists and monoamine reuptake inhibitors.
   

• The urethra is catheterized via the bladder base and continuously perfused with saline solution.
• Test compounds can be administered via various routes (i.v., p.o., i.g., s.c. or i.p.) and urethral pressure monitored up to two hours post-administration.  

• Urethral pressure
• Arterial blood pressure (on request)

• Lluel P et al, Neurourol Urodyn 26: 674, 2007
• O'Neill A et al, Life Sci 70: 181-97, 2001
• Akiyama et al, JPET 291: 81-91, 1999