SIMULTANEOUS RECORDING OF INTRAURETHRAL AND INTRAVESICAL PRESSURES

A MODEL FOR STRESS OR MIXED URINARY INCONTINENCE

In this model it is possible to simultaneously record intravesical and intraurethral pressures (in anesthetized animals) which are normally coordinated, but are modified as a result of ageing or spinal cord injury.

Rat, guinea-pig

• This model is suitable for testing compounds for effects on urethral and intravesical pressures and coordination between the bladder and urethra.
• Compounds having an effect in this model include α-adrenoceptor agonists and PDE inhibitors.

• Intravesical and urethral pressures are simultaneously recorded.
• Test compounds can be administered via various routes (i.v., p.o., i.g., s.c. or i.p.) and parameters measured for up to two hours post-administration.

• Maximum urethral pressure
• Urethral basal pressure
• Urethral relaxation during micturition
• Micturition pressure
• Micturition volume
• Basal intravesical pressure and threshold pressure for micturition

• Lluel P et al, Am J Physiol 284: R1287-95, 2003
• Kakizaki H and De Groat WC, J Urol 158: 1562-7, 1997
• Jung SY et al, J Urol 162: 204-12, 1999
• Wibberley A et al, Br J Pharmacol 136: 399-414, 2002