A MODEL FOR TUBULOINTERSTITIAL FIBROSIS, A COMMON FINAL FEATURE OF CHRONIC RENAL DISEASES PROGRESSING TO END-STAGE RENAL FAILURE
In vivo
CHRONIC UNILATERAL URETERAL OBSTRUCTION
MODEL
Accelerated tubulointerstitial fibrosis induced by unilateral ureteral obstruction.
SPECIES
Mouse
INTEREST
All the features of human obstructive nephropathy are obtained within 1 week.
DESCRIPTION MODEL
Unilateral ureteral ligation leads to the development of tubulointerstitial fibrosis.
Reference substances: angiotensin-converting enzyme inhibitors, AT1 receptor antagonists.
PARAMETERS EVALUATED
- Renal function
- Histomorphometry
- Inflammation
- Oxidative stress
- Apoptosis
- Proliferation
- Specific mRNA expression profile
SCIENTIFIC PUBLICATIONS
- Schanstra JP et al, Thromb Haemost 89: 735-40, 2003
- Schanstra JP et al, J Clin Invest 110: 371-9, 2002
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