DIABETIC NEPHROPATHY

A MODEL FOR CHRONIC COMPLICATIONS OF HUMAN DIABETES OR END-STAGE RENAL DISEASE

• Streptozotocin-induced diabetes (1)
• db/db mice (2)

Rat (1), mouse (2)

Depending on your compounds and objectives, NOD mouse (type 1 diabetes) and Zucker rat (type 2 diabetes) strains are also available. Please contact us for further information.
 

(1) Similar features with the human type 1 diabetes are reproduced.

(2) Most of the characteristic features of the human type 2 diabetes are present.
 

(1) Streptozotocin treatment causes complete pancreatic b-cell necrosis leading to the absence of insulin secretion.

(2) This mouse strain is characterized by a lack of leptin signaling that induces hyperphagia and hyperinsulinemia.

Reference substances: angiotensin-converting enzyme inhibitors, AT1 receptor antagonists.
 

• Renal function
• Histomorphometry
• Inflammation
• Oxidative stress
• Apoptosis
• Proliferation
• Fibrosis
• Specific mRNA expression profile
   

• Cellier E et al, Am J Physiol Renal Physiol 284: 282-92, 2003
• Mage M et al, Can J Physiol Pharmacol 80: 328-33, 2002
• Girolami JP et al, Can J Physiol Pharmacol 73: 848-53, 1995